Session 07. Genetic defects in cattle – identification, finding the mutation and managing it in breeding plans

Date: 28 August 2017; 14:00 – 17:30 hours
Chairperson: H.Jorjani

Theatre Session 07

Implications of mosaicism for deleterious de novo mutations in artificial insemination bulls
Pausch, H.; Wurmser, C.; Ammermueller, S.; Segelke, D.; Capitan, A.; Fries, R.

Genotype prediction for a structural variant in Brown Swiss cattle (BSW) using Illumina Beadchip data
Seefried, F.R.; Von Rohr, P.; Drögemüller, C.

Chasing deleterious variants in Holstein dairy cattle
Ajmone Marsan, P.; Milanesi, M.; Capomaccio, S.; Colli, L.; Biffani, S.; Van Kaam, J.T.; Finocchiaro, R.; Negrini, R.; Rubin, C.J.; Nardone, A.; Maciotta, N.P.P.; Williams, J.L.

RP1: an example of reverse genetics approach to describe common recessive defects
Grohs, C.; Michot, P.; Chahory, S.; Deloche, M.C.; Barbey, S.; Boussaha, M.; Danchin-Burge, C.; Fritz, S.; Boichard, D.; Capitan, A.

Identification and management of genetic recessive defects in Belgian Blue beef cattle
Druet, T.; Sartelet, A.; Hubin, X.; Tamma, N.; Georges, M.; Charlier, C.

A review of bioinformatic methods to locate a new recessive mutation on the genome
Invited Pollott, G.E.

Managing lethal alleles using genomic optimum contribution selection
Hjortø, L.; Thomasen, J.R.; Berg, P.; Kargo, M.; Henryon, M.; Liu, H.; Sørensen, A.C.

Using a MQTL matrix to test for pleiotropic effects of Mendelian trait loci on quantitative traits.
Scheper, C.; König, S.

Bovine Genetic Disease and Trait Frequencies in Ireland: >85 causative alleles in >1M animals
Mcclure, M.C.; Flynn, P.; Weld, R.; Pabiou, T.; Mullen, M.; Kearney, J.F.; Mcclure, J.

Management of Mendelian traits in breeding programs by gene editing
Invited Cole, J.B.

International registration and management of genetic defects: General discussion
Jorjani, H.



Poster Session 07

APOB associated cholesterol deficiency in Holstein cattle is not a simple recessive disease
Schuler, U.; Berweger, M.; Gredler-Grandl, B.; Kunz, S.; Hofstetter, S.; Mock, T.; Mehinagic, T.; Stokar-Regenscheit, M.; Meylan, M.; Schmitz-Hsu, F.; Seefried, F.R.; Drögemüller, C.


Associations between a causal mutation for Mulefoot and production traits in Holstein Friesian cows
Mullen, M.P.; Mcclure, J.; Kearney, F.; Mcclure, M.

Relationships between mutations responsible for Holstein Haplotype 1, 3 and 4 and Bovine Leukocyte A
Mcclure, M.; Mcclure, J.; Ratcliffe, L.; Kearney, J.F.; Mullen, M.

A region on BTA5 is significantly associated with Brachygnathia inferior in dairy cattle
Flury, C.; Signer-Hasler, H.; Frischknecht, M.; Lussi, A.; Seefried, F.R.; Drögemüller, C.

Screening for missing homozygosity in a local Swiss dual purpose breed
Seefried, F.R.; Berweger, M.; Gredler-Grandl, B.; Kunz, S.; Drögemüller, C.

Searching for, finding, and fixing genetic diseases: We can’t afford not to
Mcclure, J.; Flynn, P.; Waters, S.; Kearney, F.; Mullen, M.; Pabiou, T.; Schnabel, R.; Taylor, J.; Weld, R.; Mcclure, M.

Genetic basis of the intrauterine growth restriction (IUGR) in cattle
Rutkowska, K.; Lukaszewicz, M.; Oprzadek, J.